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UCPs exhibit neuroprotective effects by regulating proton transport and reducing the production of ROS [70]

This is consistent with our hypothesis that this group would include patients in whom excitotoxic damage during acute florid illness has led to subsequent reductions in mental and neural activity mediated by glutamatergic neurotransmission [3, 4]

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A 2020 review on the safety of BPC-157 in preclinical (animal) studies states that the peptide did not show any test-related effects in the single-dose toxicity study and that it was well tolerated in repeat-dose evaluations.16 Other animal studies and reviews mention that BPC-157 has no reported toxicity or that it was without a lethal dose in toxicology studies.14 17 Even the authors of a small human study on BPC-157 for interstitial cystitis note that no one dropped out of the study, and no adverse events were reported.18 We want to highlight that most of the relevant studies have been conducted on animals, and more human research is needed

A preference for certain protein nucleophiles has been noted in in chemico assays using skin sensitizers, 14,20,24 but the selectivity of some chemicals for certain nucleophiles is also observed when haptenation is studied in more complex systems in vitro